In hopes of curing more people with sickle cell, researchers are turning to gene editing. One company, CRISPR Therapeuti

A friend once told me about how her dad cheated on her mom. I was shocked, mostly because her parents were still together. Back in the day, after her mom gave birth to her third child, she fell into a deep depression. She didn’t leave her room and wasn’t there for her kids. And, of course, this took a toll on her husband.

At the February AAAS meeting, Gates called the approach “very promising” but added that the procedure’s complexities mean it can’t be used broadly in low-income countries.

“It works, but it’s just not widely deployable,” Laura Sepp-Lorenzino, PhD, chief scientific officer of Intellia Therapeutics, which received a grant of $2.8 million from the Gates Foundation in November, tells Future Human. The company, based in Cambridge, Massachusetts, was co-founded by CRISPR pioneer and Nobel Prize winner Jennifer Doudna, PhD.

Well, in the long-run, it will. Your friends and family won’t matter to a person who doesn’t value their own circle of friends. That deep connection will only be something you two share (if they’re even able to deeply connect with you).

Instagram blew up because it solved two problems at once: it allowed users to make their photos pretty with a click of a button, and it provided a platform for users to actually share their photos.

By having your own solid network of relationships, you end up attracting that into your own life. Whether it be because you have mutual acquaintances, or that someone who doesn’t value friendship can’t be with someone who does.

“The goal here is to not have the multidecade lag between when a breakthrough is available in the United States and when it gets out broadly to help anyone,” Gates said in February.

So far, at least two people have been treated with the approach, and it appears effective, but there are downsides. It requires an expensive and complicated procedure that involves altering cells outside of the body, which can prove impractical in resource-poor countries. Similar to a bone marrow transplant, people first need to undergo a high dose of chemotherapy to make room for the newly edited cells. This requires several weeks in the hospital and often comes with side effects like nausea, vomiting, and fatigue.

When someone has a revolving door of friends in their life, it says a lot about what they value most. And, for my ex, it also showed he had zero conflict resolution skills.

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elationship was notoriously tumultuous — they both had frequent adulterous affairs. Rivera’s affairs often left Kahlo feeling heartbroken and despondent (this emotional trauma was the subject of many of her paintings) Her famous fling with Leon Trotsky was partly driven by a desire to retaliate for her husband’s betrayal.

Intellia plans to use CRISPR directly inside the body to edit a person’s blood stem cells. Doing so is potentially risky because the gene-editing molecules need to find their way to the right cells. In contrast, CRISPR Therapeutics is editing cells outside the body, which allows scientists to make precise edits and to meticulously check their work before returning the cells to a person.

The problem Kevin stumbled upon with Burbn was that people did want to share their lives via photos, but they weren’t satisfied with the quality of their images. Back when iPhone 4 was the hottest smartphone available, photo quality was a serious problem.

Intellia’s scientists are engineering microscopic vessels called lipid nanoparticles — essentially tiny fat bubbles — to carry CRISPR to the bone marrow. The nanoparticles are biodegradable and are meant to break down after reaching their target in the body. They’re also easy to manufacture and can be scaled up, Sepp-Lorenzino said. The company envisions that the therapy would be given in an outpatient procedure via an IV, which are used widely even in developing countries.

When we broke up, I stayed friends with his best friend at the time. We checked in with one another now and then—grabbed drinks when I was in his area. And on one night when I met up with him (two years after the breakup), he told me my ex blew up on him. They haven’t been friends since.

When I found sobriety in 2013, my family wanted me to play it safe. “Do something you’re familiar with,” they said, “don’t take any risks.” It came out of both love and fear, but in reality, they were playing by societal norms.