The 28-year-old revealed that she would be taking no part at Flushing Meadows on her official Facebook page.
'Unfortunately I will not be able to compete in this year's U.S. Open,' Sharapova wrote.
'I have done everything possible to be ready but it was just not enough time.
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'To all my amazing fans, I will be back in the Asian swing in a few weeks and look forward to finishing the year healthy and strong.'
The 2006 U.S. Open winner has been out of action since her semifinal defeat to Serena Williams at Wimbledon in July.
The Russian, who was seeded third for the tournament, will be replaced by her compatriot Daria Kasatkina -- who faces Australia's world No. 37 Daria Gavrilova on Monday.
Sharapova was in the same half of the draw as defending champion Serena Williams, and potentially they could have faced each other in the semifinals.
Williams' bid for a seventh U.S. Open title and tennis' first calendar grand slam since Steffi Graf in 1988 starts Monday.
The world No. 1 faces 86th-ranked Russian Vitalia Diatchenko in the first round.
Read: The tennis stars who believe Serena is beatable
Who will win the U.S. Open? Have your say on CNN Sport's Facebook page
Sharapova was in the same half of the draw as defending champion Serena Williams, and potentially they could have faced each other in the semifinals. The world No. 1 faces 86th-ranked Russian Vitalia Diatchenko in the first round. The 28-year-old revealed that she would be taking no part at Flushing Meadows on her official Facebook page. The Russian, who was seeded third for the tournament, will be replaced by her compatriot Daria Kasatkina -- who faces Australia's world No. 37 Daria Gavrilova on Monday. The Russian, who was seeded third for the tournament, will be replaced by her compatriot Daria Kasatkina -- who faces Australia's world No. 37 Daria Gavrilova on Monday. 'To all my amazing fans, I will be back in the Asian swing in a few weeks and look forward to finishing the year healthy and strong.' 'Unfortunately I will not be able to compete in this year's U.S. Open,' Sharapova wrote. The Russian, who was seeded third for the tournament, will be replaced by her compatriot Daria Kasatkina -- who faces Australia's world No. 37 Daria Gavrilova on Monday. The 28-year-old revealed that she would be taking no part at Flushing Meadows on her official Facebook page. The 2006 U.S. Open winner has been out of action since her semifinal defeat to Serena Williams at Wimbledon in July. 'To all my amazing fans, I will be back in the Asian swing in a few weeks and look forward to finishing the year healthy and strong.' The 2006 U.S. Open winner has been out of action since her semifinal defeat to Serena Williams at Wimbledon in July. Read: The tennis stars who believe Serena is beatable Sharapova was in the same half of the draw as defending champion Serena Williams, and potentially they could have faced each other in the semifinals. Williams' bid for a seventh U.S. Open title and tennis' first calendar grand slam since Steffi Graf in 1988 starts Monday. 'I have done everything possible to be ready but it was just not enough time. Sharapova was in the same half of the draw as defending champion Serena Williams, and potentially they could have faced each other in the semifinals. The 28-year-old revealed that she would be taking no part at Flushing Meadows on her official Facebook page. 'To all my amazing fans, I will be back in the Asian swing in a few weeks and look forward to finishing the year healthy and strong.' The 2006 U.S. Open winner has been out of action since her semifinal defeat to Serena Williams at Wimbledon in July. The Russian, who was seeded third for the tournament, will be replaced by her compatriot Daria Kasatkina -- who faces Australia's world No. 37 Daria Gavrilova on Monday. Read: The tennis stars who believe Serena is beatable The world No. 1 faces 86th-ranked Russian Vitalia Diatchenko in the first round. The 28-year-old revealed that she would be taking no part at Flushing Meadows on her official Facebook page. The Russian, who was seeded third for the tournament, will be replaced by her compatriot Daria Kasatkina -- who faces Australia's world No. 37 Daria Gavrilova on Monday. The 2006 U.S. Open winner has been out of action since her semifinal defeat to Serena Williams at Wimbledon in July. The 28-year-old revealed that she would be taking no part at Flushing Meadows on her official Facebook page. Who will win the U.S. Open? Have your say on CNN Sport's Facebook page The world No. 1 faces 86th-ranked Russian Vitalia Diatchenko in the first round. Read: The tennis stars who believe Serena is beatable Williams' bid for a seventh U.S. Open title and tennis' first calendar grand slam since Steffi Graf in 1988 starts Monday. Williams' bid for a seventh U.S. Open title and tennis' first calendar grand slam since Steffi Graf in 1988 starts Monday. 'To all my amazing fans, I will be back in the Asian swing in a few weeks and look forward to finishing the year healthy and strong.' The 28-year-old revealed that she would be taking no part at Flushing Meadows on her official Facebook page.
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