Bispecific antibody therapeutics market is projected to grow at an annualized rate of ~16%, in the span of 2019 to 2030

Roots Analysis has done a detailed study on Bispecific Antibody Therapeutics Market (4th Edition), 2020-2030, covering key aspects of the industry’s evolution and identifying potential future growth opportunities.

 

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Key Market Insights         

• With two approved drugs and close to 300 clinical / preclinical product candidates, the bispecific antibody therapeutics pipeline has evolved significantly over the past few years
• The pipeline features drug candidates that target a wide range of biological antigens based on different antibody formats through novel mechanisms of action; more than 50% of these act by retargeting or activation of T-Cells
• To gain a competitive edge in the market, developers are actively exploring novel biological targets and mechanisms of action to treat diverse disease indications
• Although start-ups and mid-sized firms are spearheading the innovation, several big pharmaceutical companies are also actively engaged
• In order to cater to the evolving needs of developers, technology providers have established presence across different regions; the US and EU have emerged as the key hubs
• Close to 50,000 patients were estimated to have been enrolled in clinical trials evaluating bispecific antibody therapeutics, across various geographical locations and phases of development
• The increasing interest of stakeholders in this domain can also be gauged by the rising product development / commercialization, R&D and technology licensing deals being signed across various regions
• Given the complexities associated with the development of bispecific antibodies, contract organizations have become an indispensable part of the development and manufacturing process of antibody therapeutics
• In order to keep patients and healthcare professionals informed and aware of the developments, companies are deploying diverse promotional strategies for their respective products

 

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Table of Contents

 

1.                     PREFACE
1.1.                   Chapter Outlines
1.2.                   Research Methodology
1.3.                   Chapter Outlines
 

2.                     EXECUTIVE SUMMARY

 

3.                     INTRODUCTION

3.1.                   Chapter Overview

3.2.                   Concept of an Antibody

3.3.                   Structure of an Antibody

3.4.                   Functions of an Antibody

3.5.                   Mechanism of Action of an Antibody

3.6.                   Concept of Monoclonal Antibodies

3.7.                   Antibody Therapeutics

3.8.                   Historical Evolution of Antibody Therapeutics

                       

3.9.                   Types of Advanced Antibody Therapeutics        

3.9.1.                Fc Engineered and Glycoengineered Antibodies

3.9.2.                Antibody Fragments

3.9.3.                Fusion Proteins

3.9.4.                Intrabodies

3.9.5.                Bispecific Antibodies

                       

3.10.                 Bispecific Antibody Formats

3.10.1.              Single-Chain-based Formats (Fc Independent Antibody Formats)

3.10.1.1.           Tandem scFvs (single-chain variable fragments) and Triple bodies         

3.10.1.2.           Bispecific Single-Domain Antibody Fusion Proteins        

3.10.1.3.           Diabodies / Diabody Derivatives

3.10.1.4.           Fusion Proteins

3.10.1.5.           Fusion Proteins Devoid of Fc Regions   

3.10.2.              Immunoglobulin G (IgG)-based Formats (Fc Dependent Antibody Formats)         

3.10.2.1.           Quadromas      

3.10.2.2.           Knobs-Into-Holes         

3.10.2.3.           Dual Variable Domain Ig           

3.10.2.4.           IgG-scFv          

3.10.2.5.           Two-in-one or Dual Action Fab (DAF) Antibodies

3.10.2.6.           Half Molecule Exchange

3.10.2.7.           κλ- Bodies       

                       

3.11.                 Mechanisms of Action of Bispecific Antibodies   

3.11.1.              Retargeting Immune Effectors (NK Cells and T Cells) to Tumor Cells      

3.11.2.              Directly Targeting Malignant / Tumor Cells

3.11.3.              Retargeting of Toxins

3.11.5.              Targeting Tumor Angiogenesis

3.11.6.              Other Mechanisms

                       

3.12.                 Applications of Bispecific Antibodies

                       

4                      MARKET OVERVIEW

4.1.                   Chapter Overview

4.2.                   Bispecific Antibody Therapeutics: Developer Landscape

4.2.1.                Analysis by Year of Establishment

4.2.2.                Analysis by Company Size

4.2.3.                Analysis by Geographical Location

                       

4.3.                   Bispecific Antibody Therapeutics: Clinical Pipeline

4.3.1.                Analysis by Phase of Development

4.3.2.                Analysis by Target Antigen

4.3.3.                Analysis by Type of Antibody Format

4.3.4.                Analysis by Mechanism of Action

4.3.5.                Analysis by Disease Indication

4.3.6.                Analysis by Therapeutic Area

4.3.7.                Analysis by Broader Disease Segment

4.3.8.                Analysis by Route of Administration

4.3.9.                Analysis by Mode of Administration

4.3.10.              Analysis by Patient Segment

4.4.                   Bispecific Antibody Therapeutics: Early Stage Pipeline

4.4.1.                Analysis by Phase of Development