“If you’re getting a vaccine that requires two doses, that’s because you need that second dose, you

Author : fastitem123

Publish Date : 2021-01-09 15:53:10

Both the Pfizer and the Moderna vaccines require two doses, though some of the other vaccines may require only one dose. If people don’t return for the second dose, the vaccine won’t be as effective, Hamburg said.

“If you’re getting a vaccine that requires two doses, that’s because you need that second dose, you need that boost in order to mount the level of immune response that vaccine can provide, and that second dose really does make a difference,” she said.

Q: Can I get my first dose of one vaccine and my second dose of a different vaccine?

The FDA only approves vaccines to be given according to how they were tested in clinical trials, which then determines how the CDC will recommend they are administered. Right now, the vaccines have only been tested singularly. No study has looked at getting one dose of a Pfizer vaccine and then a dose of the Moderna vaccine, for example. Therefore, people should only get a second dose of the same vaccine they received for the first dose. Later research might find that mixing and matching is safe and effective, as researchers eventually determined with two different types of rotavirus vaccines for children. But until those studies have been done, stick with the same one.

Q: How can I read how the studies are being conducted?

The procedures for every study are published at ClinicalTrials.gov. At that site, type in “Covid-19” in the “Condition or disease” search bar and then “vaccine” and the manufacturer’s name in the “Other terms” search bar, and it will pull up all the Covid-19 vaccine trials for that manufacturer.

In addition, in a move of transparency that’s highly unusual for vaccine trials, companies have published their detailed clinical trial protocols online. The BMJ has collected them all in one place; see the references at the bottom of this editorial. It will also be possible to read the procedures of each trial in detail as the data for each vaccine becomes publicly available after submission to the FDA.

Q: Will the vaccine protect against other coronavirus diseases?

Sometimes a vaccine for one pathogen offers limited protection against a very similar pathogen, a phenomenon called cross-strain protections. This is most often seen with flu vaccines when several circulating flu viruses share very similar genetic code. But the SARS-CoV-2 virus doesn’t resemble any of the coronaviruses that cause colds.

“We do not expect any cross-protection against other coronavirus infections since the vaccines trigger an immune response to the SARS-CoV-2 spike protein,” Belongia said. “The immune system sees this as distinct from other human coronaviruses with little or no cross-reactivity. Seasonal coronaviruses cause mild upper respiratory illness, and the focus of vaccine development has been to prevent serious illness due to Covid-19.”

But we can’t completely rule out cross-strain protection against a new coronavirus that comes along later, or even SARS-CoV (which causes SARS) if it returns, said Maria Elena Bottazzi, PhD, associate dean of the National School of Tropical Medicine at Baylor College of Medicine and co-director of Texas Children’s Hospital Center for Vaccine Development.

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