Roots Analysis has done a detailed study on Targeted Protein Degradation Market: Focus on Therapeutics and Technology Platforms (based on Degronimids, ENDTACs, Epichaperome Inhibitors, Hydrophobic Tags, IMiDs, LYTACs, Molecular Glues, PHOTACs, PROTACs, Protein Homeostatic Modulators, SARDs, SERDs, SNIPERs, and Specific BET and DUB Inhibitors), 2020-2030, covering key aspects of the industry’s evolution and identifying potential future growth opportunities.
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Key Market Insights
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Table of Contents
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
3.1. Context and Background
3.2. Concept of Protein Homeostasis
3.3. Discovery of the Ubiquitin Proteasome System
3.3.1. Ubiquitin: Structure and Function
3.3.2. Fundamentals of the UPS
3.3.3. Components of the UPS
3.4. Key Steps Involved in the UPS
3.4.1. Ubiquitination: The First Step
3.4.2. Proteasomal Degradation: The Second Step
3.5. Therapeutic Applications of the UPS
3.6. Advantages and Challenges Associated with Ubiquitin Enzyme Inhibitors
3.7. Targeted Protein Degradation: Enhancing Ubiquitination to Degrade Undruggable Targets
3.7.1. Brief History of Targeted Protein Degradation
3.8. Types of Protein Degraders
3.8.1. Selective Hormone Receptor Degraders (SHRDs)
3.8.2. Immumodulatory Imide Drugs (IMiDs)
3.8.3. PROTACs
3.8.4. Other Chimeras (ENDTACs, LYTACs and PHOTACs)
3.8.4.1. Endosome Targeting Chimeras (ENDTACs)
3.8.4.2. Lysozyme targeting chimeras (LYTACs)
3.8.5. Specific and Nongenetic Inhibitor-of-Apoptosis Proteins (IAP)-dependent Protein Erasers (SNIPERS)
3.8.6. Hydrophobic Tag
3.8.7. Molecular Glues
3.8.8. DUB Inhibitors
3.9. Growth Drivers and Roadblocks
4.1. Chapter Overview
4.2. Targeted Protein Degradation-based Therapeutics and Technologies: Development Pipeline
4.2.1. Analysis by Type of Protein Degrader
4.2.2. Analysis by Phase of Development
4.2.3. Analysis by Therapeutic Area
4.2.4. Analysis by Target Indication
4.2.5. Analysis by Type of Target Enzyme
4.2.6. Analysis by Type of Target Protein
4.2.7. Analysis by Type of Therapy
4.2.8. Analysis by Route of Administration
4.3. Targeted Protein Degradation-based Therapeutics and Technologies: List of Research Tools / Key Technology Platforms
4.4. Targeted Protein Degradation-based Therapeutics and Technologies: Developer Landscape
4.4.1. Analysis by Year of Establishment
4.4.2. Analysis by Location of Headquarters
4.4.3. Analysis by Size of Company
4.4.4. Analysis by Type of Protein Degrader
5.1. Chapter Overview
5.2. Developers with Clinical Candidates
5.2.1. Radius Health
5.2.1.1. Company Overview
5.2.1.2. Targeted Protein Degradation-based Drug Portfolio
5.2.1.2.1. Product Description: Elacestrant
5.2.1.3. Recent Developments and Future Outlook
5.2.2. Celgene
5.2.2.1. Company Overview
5.2.2.2. Financial Information
5.2.2.3. Targeted Protein Degradation-based Drug Portfolio
5.2.2.3.1. Avadomide (CC-122)
5.2.2.3.2. Iberdomide (CC-220)
5.2.2.4. Recent Developments and Future Outlook
5.2.3. Sanofi Genzyme
5.2.3.1. Company Overview
5.2.3.2. Financial Information
5.2.3.3. Targeted Protein Degradation-based Drug Portfoli
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